Monday, March 2, 2020
7:15 am – 8:30 am
Check-in and Continental Breakfast
8:30 am – 9:20 am
Overview: The Neurotherapeutics Discovery and Development Process
Michael A. Rogawski, MD, PhD, University of California, Davis
9:20 am – 10:10 am
Session 1: Target and Pathway Interrogation
James Inglese, PhD, National Center for Advancing Translational Sciences, NIH
10:10 am – 10:30 am
Break
10:30 am – 11:20 am
Session 2: Biology Basics for Identifying Hits
William Janzen, BS, Ribometrix, Inc.
11:20 am – 12:10 am
Session 3: Moving from Hit to Lead to Clinical Candidate
James Barrow, PhD, Johns Hopkins School of Medicine
12:10 noon – 1:40 pm
Lunch/Afternoon Break
Students paired with mentors
Vignettes: Success Stories in Neurotherapeutics Discovery
1:40 pm – 2:10 pm
Barbara Slusher, PhD, MAS, Johns Hopkins Drug Discovery, Johns Hopkins University
2:10 pm – 2:40 pm
Karl Scheidt, PhD, Northwestern University
2:40 pm – 3:00 pm
Break
3:00 pm – 3:50 pm
Session 4: Antibody-Based Therapies
Gai Ayalon, PhD, Ultragenyx
3:50 pm – 4:40 pm
Session 5: Intellectual Property
Jeffrey W. Childers, PhD, Casimir Jones S.C.
4:40 pm – 5:00 pm
Break
5:00 pm – 6:00 pm
Networking Reception
with ASENT participants
6:00 pm – 8:00 pm
Dinner
ASENT Careers Program
Tuesday, March 3, 2020
7:15 am – 8:00 am
Continental Breakfast
8:00 am – 8:50 am
Session 6: Alternative Approaches to Lead Generation
Sam J. Enna, PhD, The University of Kansas
8:50 am – 9:40 am
Session 7: ADME
Kennan Marsh, PhD, AbbVie
9:40 am – 10:00 am
Break
10:00 am – 10:50 am
Session 8: Preclinical Models of CNS Disease: Efficacy and Target Engagement
Christian Mirescu, PhD, Merck
10:50 pm – 11:40 pm
Session 9: Rigor in Translational Drug Discovery and Development
Shai Silberberg, PhD, NIH/NINDS
12:00 noon – 1:50 pm
Lunch
Responsible Conduct of Research Exercise
1:50 pm – 2:40 pm
Session 10: Formulation and Route of Administration
James Cloyd III, PharmD, University of Minnesota
2:40 pm – 3:30 pm
Session 11: Gene Therapy with Viral Vectors
Edgardo Rodríguez-Lebrón, PhD, McKnight Brain Institute, University of Florida
3:30 pm – 5:30 pm
Engagement Exercise 1: Round Robin Day 1
5:30 pm – 6:00 pm
Break
6:00 pm – 8:30 pm
Course Dinner and After Dinner Talk
Joseph R. Moskal, PhD, Falk Center for Molecular Therapeutics,
Northwestern University
Wednesday, March 4, 2020
7:15 am – 8:00 am
Continental Breakfast
8:00 am – 8:50 am
Session 12: Toxicology
Adaline Smith, PhD, DABT, Ironwood Pharmaceuticals
8:50 am –9:40 am
Session 13: IND Enabling Studies and Preparation of the IND
Edward Spack, PhD, Medared
9:40 am – 10:00 am
Break
10:00 am – 10:50 am
Session 14: Antisense Oligonucleotides
Gene Liau, PhD, Stoke Therapeutics
10:50 am – 11:40 am
Session 15: Clinical Considerations in the Non-Clinical Phase of Drug Discovery and Development
James J. Vornov, MD, PhD, Johns Hopkins School of Medicine and Medpace
12:00 pm – 1:30 pm
Lunch
Regency Foyer
or
ASENT2020 Lunch Panel Discussion: Small Business Innovation Research (SBIR) Funding for CNS Diseases
1:30 pm – 2:20 pm
Session 16: Funding Academic Drug Discovery Research
Charles L. Cywin, PhD, NIH/NINDS
2:20 pm – 2:30 pm
Break
2:30 pm – 5:00 pm
Engagement Exercise 2: Round Robin
5:10 pm – 6:00 pm
Break
6:00 pm – 8:30 pm
Course Dinner
Cesco Osteria, 7401 Woodmont Avenue, Bethesda
Thursday, March 5, 2020
7:15 am – 8:00 am
Continental Breakfast
8:00 am – 11:30 am
Engagement Exercise 3: Student Presentations
11:30 am – 12:00 pm
Conclusion: Where do we go from here? Course evaluation and survey
Course Directors
12:00 pm
Adjourn
