Wednesday, March 16, 2016
7:45 am – 8:45 am
Check-in and Continental Breakfast
8:45 am – 9:45 am
Overview: The Neurotherapeutics Discovery and Development Process
Michael A. Rogawski, MD, PhD, University of California, Davis
9:45 am – 10:45 am
Session 1: Target and Pathway Interrogation
James Inglese, PhD, National Center for Advancing Translational Sciences, NIH
10:45 am – 11:00 am
Break
11:00 am – 12:00 am
Session 2: Biology Basics for Identifying Hits
William Janzen, BS, Epizyme, Inc.
12:00 pm – 1:15 pm
Lunch
Students paired with mentors
1:20 am – 2:30 am
Session 3: Moving from Hit To Lead to Clinical Candidate and Medicinal Chemistry
James Barrow, PhD, Johns Hopkins School of Medicine
2:30 pm – 3:30 pm
Session 4: Alternative Approaches to Lead Generation
Sam Enna, PhD, University of Kansas Medical Center
3:30 pm – 3:45 pm
Break
3:45 pm – 5:30 pm
Engagement Exercise 1: Clarify vision statement and begin to develop the components of presentation
5:30 pm – 6:15 pm
Networking Reception
6:15 pm – 7:15 pm
Dinner
7:15 pm – 9:00 pm
After Dinner Talk – Personal Reflections on the Development of Gliadel for Brain Cancer
Henry Brem, MD, Harvey Cushing Professor, Professor of Neurosurgery, Ophthalmology, Oncology and Biomedical Engineering; Director, Department of Neurosurgery; Director, Hunterian Neurosurgical Research Laboratory; Johns Hopkins University School of Medicine
Thursday, March 17, 2016
7:15 am – 8:00 am
Continental Breakfast
8:00 am – 9:00 am
Sesssion 5: Intellectual Property
Kenneth Weber, PhD, JD, Kilpatrick Townsed
9:00 am – 10:00 am
Session 6: ADME
Kennan Marsh, PhD, AbbVie
10:00 am – 10:15 am
Break
10:15 am – 11:15 am
Session 7: In Vivo Studies
Jaqueline Crawley, PhD, University of California, Davis
11:15 am – 12:15 pm
Session 8: Preclinical Proof of Concept/Target Engagement Studies
Beth Hoffman, PhD, Huntington's Disease Society of America
12:15 pm – 1:30 pm
Lunch
Responsible Conduct of Research Exercise
1:30 pm – 5:30 pm
Engagement Exercise 2: Round Robin
5:30 pm – 6:00 pm
Networking Reception (ASENT Annual Meeting)
6:00 pm – 8:30 pm
Dinner (ASENT Annual Meeting)
Career Opportunities in Neuroscience Program
8:30 pm – 9:30 pm
Reserved for Students to Prepare Presentations
(mentors available)
Friday, March 18, 2016
7:00 am – 7:45 am
Continental Breakfast
7:45 am – 8:45 am
Lecture 9: Toxicology
Adaline Smith, PhD, DABT, Ironwood Pharmaceuticals
8:45 am –9:45 am
Lecture 10: IND Enabling Studies and Preparation of the IND
William M. Bracken, AbbVie Research and Development
9:45 am – 10:00 am
Break
10:00 am – 11:00 pm
Lecture 11: Case Studies
Barbara Slusher, PhD, Johns Hopkins University and Karl A. Scheidt, PhD, Northwestern University
11:00 pm – 12:00 pm
Lecture 12: Formulation and Route of Administration
James E. Polli, PhD, University of Maryland, School of Pharmacy
12:00 pm – 1:00 pm
Lunch
1:00 pm – 3:30 pm
ASENT Pipeline Presentation Session
4:00 pm – 6:30 pm
ASENT Pipeline Reception
6:30 pm – 8:30 pm
Course Dinner
Positano Ristorante Italiano, 4940-4948 Fairmont Ave., Bethesda, MD 20814
Transportation: LW Transportation will pick-up at Marriott at 6:30 p.m.
Saturday, March 19, 2016
7:15 am – 8:00 am
Continental Breakfast
8:00 – 9:00 am
Session 13: Rigor in Translational Drug Discovery and Development
Shai Silberberg, PhD, NIH/NINDS
9:00 am – 10:15 am
Engagement Exercise 3: Student Presentations
10:15 am – 10:30 am
Break
10:30 am – 11:30 am
Engagement Exercise 3: Student Presentations (continued)
11:30 am – 12:30 pm
Session 14: Funding Academic Drug Discovery Research
Charles L. Cywin, PhD, NIH/NINDS
12:30 pm – 12:45 pm
Conclusion: Where do we go from here? Presentation of plan for continued mentoring, engagement and course evaluation over two-year period
Course Directors
12:45 pm
Adjourn
7:45 am – 8:45 am
Check-in and Continental Breakfast
8:45 am – 9:45 am
Overview: The Neurotherapeutics Discovery and Development Process
Michael A. Rogawski, MD, PhD, University of California, Davis
9:45 am – 10:45 am
Session 1: Target and Pathway Interrogation
James Inglese, PhD, National Center for Advancing Translational Sciences, NIH
10:45 am – 11:00 am
Break
11:00 am – 12:00 am
Session 2: Biology Basics for Identifying Hits
William Janzen, BS, Epizyme, Inc.
12:00 pm – 1:15 pm
Lunch
Students paired with mentors
1:20 am – 2:30 am
Session 3: Moving from Hit To Lead to Clinical Candidate and Medicinal Chemistry
James Barrow, PhD, Johns Hopkins School of Medicine
2:30 pm – 3:30 pm
Session 4: Alternative Approaches to Lead Generation
Sam Enna, PhD, University of Kansas Medical Center
3:30 pm – 3:45 pm
Break
3:45 pm – 5:30 pm
Engagement Exercise 1: Clarify vision statement and begin to develop the components of presentation
5:30 pm – 6:15 pm
Networking Reception
6:15 pm – 7:15 pm
Dinner
7:15 pm – 9:00 pm
After Dinner Talk – Personal Reflections on the Development of Gliadel for Brain Cancer
Henry Brem, MD, Harvey Cushing Professor, Professor of Neurosurgery, Ophthalmology, Oncology and Biomedical Engineering; Director, Department of Neurosurgery; Director, Hunterian Neurosurgical Research Laboratory; Johns Hopkins University School of Medicine
Thursday, March 17, 2016
7:15 am – 8:00 am
Continental Breakfast
8:00 am – 9:00 am
Sesssion 5: Intellectual Property
Kenneth Weber, PhD, JD, Kilpatrick Townsed
9:00 am – 10:00 am
Session 6: ADME
Kennan Marsh, PhD, AbbVie
10:00 am – 10:15 am
Break
10:15 am – 11:15 am
Session 7: In Vivo Studies
Jaqueline Crawley, PhD, University of California, Davis
11:15 am – 12:15 pm
Session 8: Preclinical Proof of Concept/Target Engagement Studies
Beth Hoffman, PhD, Huntington's Disease Society of America
12:15 pm – 1:30 pm
Lunch
Responsible Conduct of Research Exercise
1:30 pm – 5:30 pm
Engagement Exercise 2: Round Robin
5:30 pm – 6:00 pm
Networking Reception (ASENT Annual Meeting)
6:00 pm – 8:30 pm
Dinner (ASENT Annual Meeting)
Career Opportunities in Neuroscience Program
8:30 pm – 9:30 pm
Reserved for Students to Prepare Presentations
(mentors available)
Friday, March 18, 2016
7:00 am – 7:45 am
Continental Breakfast
7:45 am – 8:45 am
Lecture 9: Toxicology
Adaline Smith, PhD, DABT, Ironwood Pharmaceuticals
8:45 am –9:45 am
Lecture 10: IND Enabling Studies and Preparation of the IND
William M. Bracken, AbbVie Research and Development
9:45 am – 10:00 am
Break
10:00 am – 11:00 pm
Lecture 11: Case Studies
Barbara Slusher, PhD, Johns Hopkins University and Karl A. Scheidt, PhD, Northwestern University
11:00 pm – 12:00 pm
Lecture 12: Formulation and Route of Administration
James E. Polli, PhD, University of Maryland, School of Pharmacy
12:00 pm – 1:00 pm
Lunch
1:00 pm – 3:30 pm
ASENT Pipeline Presentation Session
4:00 pm – 6:30 pm
ASENT Pipeline Reception
6:30 pm – 8:30 pm
Course Dinner
Positano Ristorante Italiano, 4940-4948 Fairmont Ave., Bethesda, MD 20814
Transportation: LW Transportation will pick-up at Marriott at 6:30 p.m.
Saturday, March 19, 2016
7:15 am – 8:00 am
Continental Breakfast
8:00 – 9:00 am
Session 13: Rigor in Translational Drug Discovery and Development
Shai Silberberg, PhD, NIH/NINDS
9:00 am – 10:15 am
Engagement Exercise 3: Student Presentations
10:15 am – 10:30 am
Break
10:30 am – 11:30 am
Engagement Exercise 3: Student Presentations (continued)
11:30 am – 12:30 pm
Session 14: Funding Academic Drug Discovery Research
Charles L. Cywin, PhD, NIH/NINDS
12:30 pm – 12:45 pm
Conclusion: Where do we go from here? Presentation of plan for continued mentoring, engagement and course evaluation over two-year period
Course Directors
12:45 pm
Adjourn
