Mentor Assignments and Round Robin Schedule will be posted when the course begins.
Monday, February 8, 2021
11:00 am – 11:30 am
Overview: The Neurotherapeutics Discovery and Development Process
Michael A. Rogawski, MD, PhD, University of California, Davis
11:30 am – 12:15 pm
Session 1: Target and Pathway Interrogation
James Inglese, PhD, National Center for Advancing Translational Sciences, NIH
12:15 pm – 12:45 pm
Break
12:45 pm – 1:30 pm
Session 2: Biology Basics for Identifying Hits
William Janzen, BS, Ribometrix, Inc.
1:30 pm – 2:15 pm
Session 3: Moving from Hit to Lead to Clinical Candidate
James Barrow, PhD, Johns Hopkins School of Medicine
2:15 noon – 2:30 pm
Break
2:30 pm – 3:15 pm
Session 4: Antibody-Based Therapies
Gai Ayalon, PhD, Ultragenyx
3:15 pm – 4:00 pm
Meet with Mentors
4:15 pm – 5:00 pm
Office Hourse with Course Directors and Faculty
Please drop by if you have questions for them.
Tuesday, February 9, 2021
11:00 am – 11:05 am
Welcome & Overview of the Day
11:05 am – 11:50 pm
Session 5: Intellectual Property
Jeffrey W. Childers, JD, PhD, Casimir Jones S.C.
11:50 am – 12:35 pm
Invited Guest Speaker: The Story of Risdiplam/Everysdi
Alexander Stephan, PhD, Roche Pharma Research and Early Development
12:35 pm – 1:05 pm
Break
1:05 pm – 1:50 am
Session 6: ADME
Kennan Marsh, PhD, AbbVie
1:50 pm – 2:35 pm
Session 7: Preclinical Models of CNS Disease: Efficacy and Target Engagement
Christian Mirescu, PhD, Merck
2:35 pm – 2:50 pm
Break
2:50 pm – 4:15 pm
Engagement Exercise: Round Robin Day 1
4:30 pm – 5:15 pm
Office Hours with Course Directors and Faculty
Please drop by if you have questions for them.
Wednesday, February 10, 2021
11:00 am – 11:05 am
Welcome & Overview of the Day
11:05 am – 11:35 am
Session 8a: Formulation and Routes of Administration
Maureen Donovan, PhD, University of Iowa
11:35 am – 11:50 am
Session 8b: Alternative Routes of Administration
James Cloyd III, PharmD, University of Minnesota
11:50 am – 12:35 pm
Session 9: Gene Therapy
Edgardo Rodríguez-Lebrón, PhD, McKnight Brain Institute, University of Florida
12:35 am – 1:05 pm
Break
1:05 pm – 1:50 pm
Session 10: Toxicology
Adaline Smith, PhD, DABT
1:50 am – 2:35 pm
Session 11: IND Enabling Studies and Preparation of the IND
Edward Spack, PhD, Medared
2:35 pm – 2:50 pm
Break
2:50 pm – 4:15 pm
Engagement Exercise 2: Round Robin Day 2
4:30 pm – 5:15 pm
Office Hours with Course Directors and Faculty
Please drop by if you have questions for them.
Thursday, February 11, 2021
11:00 am – 11:05 am
Welcome & Overview of the Day
11:50 am – 12:35 pm
Session 13: Clinical Considerations in the Non-Clinical Phase of Drug Discovery and Development
James J. Vornov, MD, PhD, Johns Hopkins School of Medicine and Medpace
12:35 pm – 1:05 pm
Break
1:05 pm – 1:50 pm
Session 14: Funding Academic Drug Discovery Research
Charles L. Cywin, PhD, NIH/NINDS
Engagement Exercise: Round Robin 3
3:10 pm – 3:55 pm
Office Hours with Course Directors and Faculty
Please drop by if you have questions for them.
Friday, February 12, 2021
11:00 am – 11:15 am
Welcome & Overview of the Day
11:15 am – 1:45 pm
Engagement Exercise: Student Presentations
1:45 pm – 2:00 pm
Conclusion: Where do we go from here? Course evaluation and survey
Course Directors
2:00 pm
Adjourn
11:00 am – 11:30 am
Overview: The Neurotherapeutics Discovery and Development Process
Michael A. Rogawski, MD, PhD, University of California, Davis
11:30 am – 12:15 pm
Session 1: Target and Pathway Interrogation
James Inglese, PhD, National Center for Advancing Translational Sciences, NIH
12:15 pm – 12:45 pm
Break
12:45 pm – 1:30 pm
Session 2: Biology Basics for Identifying Hits
William Janzen, BS, Ribometrix, Inc.
1:30 pm – 2:15 pm
Session 3: Moving from Hit to Lead to Clinical Candidate
James Barrow, PhD, Johns Hopkins School of Medicine
2:15 noon – 2:30 pm
Break
2:30 pm – 3:15 pm
Session 4: Antibody-Based Therapies
Gai Ayalon, PhD, Ultragenyx
3:15 pm – 4:00 pm
Meet with Mentors
4:15 pm – 5:00 pm
Office Hourse with Course Directors and Faculty
Please drop by if you have questions for them.
Tuesday, February 9, 2021
11:00 am – 11:05 am
Welcome & Overview of the Day
11:05 am – 11:50 pm
Session 5: Intellectual Property
Jeffrey W. Childers, JD, PhD, Casimir Jones S.C.
11:50 am – 12:35 pm
Invited Guest Speaker: The Story of Risdiplam/Everysdi
Alexander Stephan, PhD, Roche Pharma Research and Early Development
12:35 pm – 1:05 pm
Break
1:05 pm – 1:50 am
Session 6: ADME
Kennan Marsh, PhD, AbbVie
1:50 pm – 2:35 pm
Session 7: Preclinical Models of CNS Disease: Efficacy and Target Engagement
Christian Mirescu, PhD, Merck
2:35 pm – 2:50 pm
Break
2:50 pm – 4:15 pm
Engagement Exercise: Round Robin Day 1
4:30 pm – 5:15 pm
Office Hours with Course Directors and Faculty
Please drop by if you have questions for them.
Wednesday, February 10, 2021
11:00 am – 11:05 am
Welcome & Overview of the Day
11:05 am – 11:35 am
Session 8a: Formulation and Routes of Administration
Maureen Donovan, PhD, University of Iowa
11:35 am – 11:50 am
Session 8b: Alternative Routes of Administration
James Cloyd III, PharmD, University of Minnesota
11:50 am – 12:35 pm
Session 9: Gene Therapy
Edgardo Rodríguez-Lebrón, PhD, McKnight Brain Institute, University of Florida
12:35 am – 1:05 pm
Break
1:05 pm – 1:50 pm
Session 10: Toxicology
Adaline Smith, PhD, DABT
1:50 am – 2:35 pm
Session 11: IND Enabling Studies and Preparation of the IND
Edward Spack, PhD, Medared
2:35 pm – 2:50 pm
Break
2:50 pm – 4:15 pm
Engagement Exercise 2: Round Robin Day 2
4:30 pm – 5:15 pm
Office Hours with Course Directors and Faculty
Please drop by if you have questions for them.
Thursday, February 11, 2021
11:00 am – 11:05 am
Welcome & Overview of the Day
11:50 am – 12:35 pm
Session 13: Clinical Considerations in the Non-Clinical Phase of Drug Discovery and Development
James J. Vornov, MD, PhD, Johns Hopkins School of Medicine and Medpace
12:35 pm – 1:05 pm
Break
1:05 pm – 1:50 pm
Session 14: Funding Academic Drug Discovery Research
Charles L. Cywin, PhD, NIH/NINDS
Engagement Exercise: Round Robin 3
3:10 pm – 3:55 pm
Office Hours with Course Directors and Faculty
Please drop by if you have questions for them.
Friday, February 12, 2021
11:00 am – 11:15 am
Welcome & Overview of the Day
11:15 am – 1:45 pm
Engagement Exercise: Student Presentations
1:45 pm – 2:00 pm
Conclusion: Where do we go from here? Course evaluation and survey
Course Directors
2:00 pm
Adjourn
